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Cardiovascular Physiology Concepts

Richard E. Klabunde, PhD


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Blood Flow Regulation Tutorial

This tutorial provides a systematic approach to learning by using a sequence that is like how this topic would unfold in a traditional textbook. The student is encouraged to go not only to the initial link associated with each tutorial question but also to use embedded hyperlinks to expand upon the physiological concepts associated with the question.

Quiz Questions Linked to Tutorial

At the end of the tutorial, there is a link to an external website ( that has multiple choice and true/false questions that are associated with the tutorial. When the quiz results are given to the user after taking the quiz, links are provided back to specific pages to assist learning. Users will need to register (free) on the site to access the quiz questions for the tutorial. No personal information is available to other than the user provided login name and analysis of user performance on the quiz questions. This feedback will improve content and quiz questions.


  1. Which types of vessels are most important for regulating blood flow within an organ and tissue?
  2. What intrinsic and extrinsic factors play an important role in determining vascular tone and, therefore, organ blood flow?
  3. What cellular mechanisms determine vascular smooth muscle contraction and relaxation?
  4. What G-protein and non-G-protein signal transduction pathways are important in regulating vascular smooth muscle contraction and relaxation?
  5. What tissue metabolites function as vasodilator substances?
  6. How do changes in oxygen supply, oxygen demand, and the oxygen supply/demand ratio affect the production of metabolic vasodilators?
  7. How are myogenic mechanisms involved in blood flow regulation?
  8. What is the role of endothelial-derived substances in regulating blood flow?
  9. What stimulates the formation of nitric oxide, and what are its vascular effects?
  10. Define each of the following phenomena and describe their underlying mechanisms.
    1. autoregulation
    2. active hyperemia
    3. reactive hyperemia
  11. What autonomic nerves innervate blood vessels and what are the effects of their activation on blood flow?
  12. How do mechanical forces affect blood flow in the heart?

Link to Quiz Questions:

Revised 01/31/2023

DISCLAIMER: These materials are for educational purposes only, and are not a source of medical decision-making advice.