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Cardiovascular Physiology Concepts

Richard E. Klabunde, PhD

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Cardiovascular Physiology Concepts 3e textbook cover

Click here for information on Cardiovascular Physiology Concepts, 3rd edition, a textbook published by Wolters Kluwer (2021)


Cardiovascular Physiology Concepts textbook cover

Click here for information on Normal and Abnormal Blood Pressure, a textbook published by Richard E. Klabunde (2013)


 


Histamine and Bradykinin

 

Histamine does not normally play a significant role in regulating blood flow and microvascular function. However, during tissue injury, inflammation and allergic responses, mast cells within the tissue can release large amounts of histamine that can have pronounced vascular effects. Histamine, binding to vascular H1and H2 receptors, causes arteriolar vasodilation, venous constriction in some vascular beds, and increased capillary permeability. These effects increase local blood flow and cause tissue edema.

The actions of bradykinin are like histamine. Bradykinin binding to vascular bradykinin receptors is a potent stimulator of nitric oxide formation by vascular endothelium. It also stimulates prostacyclin formation.

Revised 01/01/2023

 

DISCLAIMER: These materials are for educational purposes only, and are not a source of medical decision-making advice.