Heart Model
Cardiovascular Physiology Concepts Richard E. Klabunde, PhD

Cardiovascular Physiology Concepts 3e textbook cover Cardiovascular Physiology Concepts, 3rd edition textbook, Published by Wolters Kluwer (2021)

CNormal and Abnormal Blood Pressure, Physiology, Pathophysiology and Treatment book cover Normal and Abnormal Blood Pressure, published by Richard E. Klabunde (2013)

Histamine and Bradykinin

Histamine does not normally play a significant role in regulating blood flow and microvascular function. However, during tissue injury, inflammation and allergic responses, mast cells within the tissue can release large amounts of histamine that can have pronounced vascular effects. Histamine, binding to vascular Hand H2 receptors, causes arteriolar vasodilation, venous constriction in some vascular beds, and increased capillary permeability. These effects increase local blood flow and cause tissue edema.

The actions of bradykinin are like histamine. Bradykinin binding to vascular bradykinin receptors is a potent stimulator of nitric oxide formation by vascular endothelium. It also stimulates prostacyclin formation. Therefore, bradykinin functions as a vasodilator during inflammation.

Revised 02/05/2024

Be sure to visit our sister site, CVPharmacology.com.

Why the Ads? CVphysiology.com is very popular with medical school students, physicians, educators, and others. We use the revenue from advertisements to offset the cost of hosting and maintaining this website. Having ads allows us to keep this website free for everyone.

Amazon Badge
Shop for Medical Books & Textbooks on Amazon