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Cardiovascular Physiology Concepts

Richard E. Klabunde, PhD

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Cardiovascular Physiology Concepts textbook cover

Click here for information on Cardiovascular Physiology Concepts, 2nd edition, a textbook published by Lippincott Williams & Wilkins (2012)


Cardiovascular Physiology Concepts textbook cover

Click here for information on Normal and Abnormal Blood Pressure, a textbook published by Richard E. Klabunde (2013)


 


Signal Transduction Mechanisms

 

The regulation of cardiac and vascular function depends on various substances (e.g., neurotransmitters, circulating hormones, paracrine substances) signaling cells to alter their function. Generally, this is accomplished through the binding of a chemical entity (ligand) to a receptor, most commonly located on the cell membrane. When a ligand binds to a receptor, the receptor signals biochemical changes within the cell that can lead to changes, for example, in muscle contraction, the firing of cardiac pacemakers, or the conduction of electrical impulses in the the heart.

There are several major signal transduction mechanisms found in cells of the cardiovascular system, the most important being the G-protein-mediated changes in cyclic AMP and inositol triphosphase (IP3), and cyclic GMP pathways. Click on the following links to read detailed descriptions of these mechanisms in cardiac cells and vascular smooth muscle cells:

Revised 4/23/2014

 

DISCLAIMER: These materials are for educational purposes only, and are not a source of medical decision-making advice.